British Air Force Typhoon jets have conducted a mission with France's air force in a combined operation against an hidden munitions depot in Syrian territory operated by the IS group, according to the UK's MoD.
The location, identified by surveillance, was assessed as housing weapons and explosive materials, the statement said, and was situated in mountainous terrain just to the north of the ancient city of Palmyra in the heart of Syria.
"Our aircraft used laser-guided Paveway IV weapons to target a series of approach shafts leading to the facility... preliminary assessments indicate the objective was successfully hit," the MoD said.
There was no sign of any civilian impact in the strike on Saturday evening and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
IS - also known as the so-called Islamic State - established militant control over significant areas in Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates British leadership, and commitment to stand shoulder to shoulder with allied nations, to eradicate any re-emergence of Daesh and their violent and radical beliefs in the Middle East," Britain's Defence Chief John Healey remarked.
British military aircraft have conducted patrols over Syria to "prevent any attempted comeback" of IS following its defeat at the Baghuz confrontation in 2019, the authorities noted.
"I extend gratitude to all the members of our armed forces involved in this mission for their expertise and their valour," Healey added. "Including them were numerous UK service members deployed over the holidays. This mission, to take out terrorist threats who pose a risk to our safety, highlights how our armed forces are always on standby, continuously, protecting the UK at home and influential overseas."
During December, the US military conducted what it described as a "massive strike" on Daesh sites in the country, subsequent to an ambush claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations says Daesh still has between 5,000 and 7,000 fighters in both countries.